SMURF 2 Recombinant Rabbit Monoclonal Antibody [JU32-34] (ET7106-76)

UNIPROT #

Q9HAU4

PROTEIN NAME

SMURF 2

SYNONYMS

E3 ubiquitin-protein ligase SMURF2 antibody;EC 6.3.2. antibody;hSMURF2 antibody;MGC138150 antibody;Smad specific E3 ubiquitin ligase 2 antibody;SMAD specific E3 ubiquitin protein ligase 2 antibody;SMAD ubiquitination regulatory factor 2 antibody;SMAD-specific E3 ubiquitin-protein ligase 2 antibody;SMUF2_HUMAN antibody;Smurf2 antibody;Ubiquitin protein ligase SMURF2 antibody

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Auto-ubiquitinated and ubiquitinated in the presence of RNF11 and UBE2D1. Ubiquitinated by the SCF(FBXL15) complex and TTC3, leading to its degradation by the proteasome.

SUBCELLULAR LOCATION

Cytoplasm. Membrane. Nucleus.

FUNCTION

Smurf1 and Smurf2 (SMAD ubiquitination regulatory factor-1 and 2) are members of the Hect family of proteins, which also includes the ubiquitin (Ub) E3-type ligases Nedd3 and E6-AP. E3 ligases are involved in the enzymatic reactions of the Ub conjugating pathway, which targets proteins for degradation by the 26S proteasome. Within the Ub pathway, the E3 ligases specifically catalyze the transfer of Ub from the Ub-conjugating enzymes to the individual protein substrate. As an E3 ligase, Smurf1 selectively interacts with receptor-regulated SMADs specific to the BMP pathway in order to trigger their ubiquitination and degradation. Smurf2 interacts with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3, but not Smad4. Although Smurf2 localizes to the nucleus, binding to Smad7 induces its export and its recruitment to the activated TGFβ receptor, where it causes degradation of Smad7.