Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Western blot analysis of SMC1 on different lysates with Rabbit anti-SMC1 antibody (ET1611-97) at 1/500 dilution.
Lane 1: Hela cell lysate
Lane 2: 293T cell lysate
Lysates/proteins at 10 µg/Lane.
Predicted band size: 143 kDa
Observed band size: 143 kDa
Exposure time: 30 seconds;
8% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (ET1611-97) at 1/500 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:300,000 dilution was used for 1 hour at room temperature.
CDLS2 antibody;DKFZp686L19178 antibody;DXhXs423e antibody;DXS423E antibody;KIAA0178 antibody;MGC138332 antibody;OTTHUMP00000061876 antibody;RP6 29D12.1 antibody;SB1.8 antibody;Segregation of mitotic chromosomes 1 antibody;Segregation of mitotic chromosomes like 1 antibody;SMC 1 antibody;SMC protein 1B antibody;SMC-1-beta antibody;SMC-1B antibody;SMC1 antibody;SMC1A antibody;SMC1alpha antibody;SMC1alpha protein antibody;SMC1B antibody;SMC1B_HUMAN antibody;SMC1BETA antibody;SMC1beta protein antibody;SMC1L1 antibody;SMC1L2 antibody;SMCB antibody;Structural maintenance of chromosome 1 like 1 protein antibody;Structural maintenance of chromosome 1 like 2 protein antibody;Structural maintenance of chromosomes 1A antibody;Structural maintenance of chromosomes 1B antibody;Structural maintenance of chromosomes protein 1B antibody
Belongs to the SMC family. SMC1 subfamily.
Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.; Phosphorylated by ATM upon ionizing radiation in a NBS1-dependent manner. Phosphorylated by ATR upon DNA methylation in a MSH2/MSH6-dependent manner. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation.
Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. SMC1A is a subunit of the cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells, cohesin is formed of SMC1A, SMC3, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.SMC1A is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation from bacteria to humans.
Just like the interactions between antigens and antibodies, the higher the affinity between you and us the better.