Lane 1: 293T cell lysate
Lane 2: Hela cell lysate
Recombinant Rabbit monoclonal primary
SMC1 Recombinant Rabbit Monoclonal Antibody [SN20-27] (ET1611-97)
Synthetic peptide within c-terminal human smc1a.
293T cell lysate, Hela cell lysate, Hela, A431, SW480, human breast carcinoma tissue, human tonsil tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
CDLS2 antibody; DKFZp686L19178 antibody; DXhXs423e antibody; DXS423E antibody; KIAA0178 antibody; MGC138332 antibody; OTTHUMP00000061876 antibody; RP6 29D12.1 antibody; SB1.8 antibody; Segregation of mitotic chromosomes 1 antibody; Segregation of mitotic chromosomes like 1 antibody; SMC 1 antibody; SMC protein 1B antibody; SMC-1-beta antibody; SMC-1B antibody; SMC1 antibody; SMC1A antibody; SMC1alpha antibody; SMC1alpha protein antibody; SMC1B antibody; SMC1B_HUMAN antibody; SMC1BETA antibody; SMC1beta protein antibody; SMC1L1 antibody; SMC1L2 antibody; SMCB antibody; Structural maintenance of chromosome 1 like 1 protein antibody; Structural maintenance of chromosome 1 like 2 protein antibody; Structural maintenance of chromosomes 1A antibody; Structural maintenance of chromosomes 1B antibody; Structural maintenance of chromosomes protein 1B antibody
Belongs to the SMC family. SMC1 subfamily.
Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.; Phosphorylated by ATM upon ionizing radiation in a NBS1-dependent manner. Phosphorylated by ATR upon DNA methylation in a MSH2/MSH6-dependent manner. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation.
The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. SMC1α (structural maintenance of chromosomes protein 1A), also known as SMC1, SMCB, CDLS2, SB1.8, SMC1L1 or DXS423E, is a 1,233 amino acid nuclear protein that is involved in chromosome cohesion during the cell cycle. SMC1α interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role in DNA repair. SMC1α is a component of the cohesion complex, which is required for the cohesion of sister chromatids after DNA replication. Mutations in the gene encoding SMC1α may be the cause of Cornelia de Lange syndrome (CdLS), which is a clinically heterogeneous developmental disorder characterized by facial dysmorphia, upper limb malformations, growth and cognitive retardation.