SLUG Recombinant Rabbit Monoclonal Antibody [PSH07-40] (HA722828)

UNIPROT #

O43623

PROTEIN NAME

SLUG

SYNONYMS

MGC10182 antibody;Neural crest transcription factor Slug antibody;Protein snail homolog 2 antibody;Slug (chicken homolog) zinc finger protein antibody;Slug homolog zinc finger protein antibody;Slug zinc finger protein antibody;SLUGH antibody;SLUGH 1 antibody;SLUGH1 antibody;SNAI 2 antibody;Snai2 antibody;SNAI2_HUMAN antibody;Snail 2 antibody;Snail homolog 2 antibody;Snail2 antibody;WS 2D antibody;WS2D antibody;Zinc finger protein SLUG antibody;Zinc finger protein SNAI2 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

This gene encodes a member of the Snail superfamily of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. It regulates differentiation and migration of neural crest cells along with other genes (e.g. FOXD3, SOX9 and SOX10, BMPs) in embryonic life. Mutations in this gene may be associated with sporadic cases of neural tube defects. SNAI2 downregulates expression of E-cadherin in premigratory neural crest cells; thus, SNAI2 induces tightly bound epithelial cells to break into a loose mesenchymal phenotype, allowing gastrulation of mesoderm in the developing embryo. Structurally similar to anti-apoptotic Ces-1 in C. elegans, SLUG is a negative regulator of productive cell death in the developing embryo and adults.