SLC39A8 Mouse Monoclonal Antibody [A9G3] (HA601161)

UNIPROT #

Q9C0K1

PROTEIN NAME

SLC39A8

SYNONYMS

4933419D20Rik antibody;AA986696 antibody;BCG induced integral membrane protein 103 antibody;BCG induced integral membrane protein BIGMo-103 (Up-regulated by BCG-CWS) (Hypothetical protein) antibody;LIV-1 subfamily of ZIP zinc transporter 6 antibody;LZT Hs6 antibody;MGC108852 antibody;PP3105 antibody;SLC39A8 antibody;Solute carrier family 39 (zinc transporter), member 8 antibody;Solute carrier family 39 (zinc transporter), member 8 (SLC39A8) antibody;Solute carrier family 39 member 8 antibody;zinc transporter ZIP8 antibody;ZIP8 antibody;Zrt- and Irt-like protein 8 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity. Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion. Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient. Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic. May also transport iron and cobalt through membranes. Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development. Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization. Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes. Protects, for instance, cells from injury and death at the onset of inflammation. By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries. Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient.