SIRT5 Recombinant Rabbit Monoclonal Antibody [JJ084-01] (ET1701-6)

UNIPROT #

Q9NXA8

PROTEIN NAME

SIRT5

SYNONYMS

NAD dependent deacetylase sirtuin 5 antibody;NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial antibody;NAD dependent protein deacylase sirtuin 5 mitochondrial antibody;NAD-dependent protein deacylase sirtuin-5, mitochondrial antibody;Regulatory protein SIR2 homolog 5 antibody;Silent mating type information regulation 2 S.cerevisiae homolog 5 antibody;Sir2 like 5 antibody;SIR2-like protein 5 antibody;SIR2L5 antibody;SIR5_HUMAN antibody;Sirt5 antibody;Sirtuin 5 antibody;Sirtuin type 5 antibody

SEQUENCE SIMILARITIES

Belongs to the sirtuin family. Class III subfamily.

TISSUE SPECIFICITY

Widely expressed.

SUBCELLULAR LOCATION

Cytoplasm, Mitochondrion, Nucleus.

FUNCTION

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.