SIRT2 Recombinant Antibody [SN70-04] - Rat IgG1 (Chimeric) (HA601506)

UNIPROT #

Q8VDQ8

PROTEIN NAME

SIRT2

SYNONYMS

FLJ35621 antibody;FLJ37491 antibody;NAD dependent deacetylase sirtuin 2 antibody;NAD-dependent deacetylase sirtuin-2 antibody;NAD-dependent protein deacetylase sirtuin-2 antibody;Regulatory protein SIR2 homolog 2 antibody;Silencing information regulator 2 like antibody;Silent information regulator 2 antibody;SIR2 antibody;SIR2 like protein 2 antibody;Sir2 related protein type 2 antibody;SIR2, S. cerevisiae, homolog-loke 2 antibody;SIR2-like protein 2 antibody;SIR2L antibody;SIR2L2 antibody;SIRT2 antibody;SIRT2_HUMAN antibody;Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae) antibody;Sirtuin 2 antibody;Sirtuin type 2 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Midbody, Chromosome, Cell projection, Myelin membrane.

FUNCTION

The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in a NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT proteins may function via mono-ADP-ribosylation of proteins. SIRT2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis.