SFRP4 Recombinant Rabbit Monoclonal Antibody [JE41-41] (ET7109-27)

UNIPROT #

Q6FHJ7

PROTEIN NAME

SFRP4

SYNONYMS

Frizzled protein antibody;Frizzled protein human endometrium antibody;FRP 4 antibody;FRP4 antibody;FrpHE antibody;human endometrium antibody;PYL antibody;Secreted frizzled-related protein 4 antibody;sFRP-4 antibody;Sfrp4 antibody;SFRP4_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the secreted frizzled-related protein (sFRP) family.

TISSUE SPECIFICITY

Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.