SF3B1 Recombinant Rabbit Monoclonal Antibody [JB40-32] (ET7107-03)

UNIPROT #

O75533

PROTEIN NAME

SF3B1

SYNONYMS

Hsh 155 antibody;MDS antibody;Pre mRNA processing 10 antibody;Pre mRNA splicing factor SF3b 155 kDa subunit antibody;PRP 10 antibody;PRP10 antibody;PRPF 10 antibody;PRPF10 antibody;SAP 155 antibody;SAP155 antibody;SF3B 1 antibody;SF3b155 antibody;Spliceosome associated protein 155 antibody;Splicing factor 3b subunit 1 155kDa antibody;Splicing factor 3B subunit 1 antibody

SEQUENCE SIMILARITIES

Belongs to the SF3B1 family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Phosphorylation occurs concomitantly with the splicing catalytic steps. Phosphorylation on Thr-244, Thr-248 and Thr-313 by cyclin-dependent kinases promotes interaction with PPP1R8 during mitosis.; Citrullinated by PADI4.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.