SF3A1 Rabbit Polyclonal Antibody (HA500235)

UNIPROT #

Q15459

PROTEIN NAME

SF3A1

SYNONYMS

Pre mRNA processing 21 antibody;Pre mRNA splicing factor SF3a antibody;PRP21 antibody;PRPF21 antibody;SAP 114 antibody;SAP114 antibody;sf3a1 antibody;SF3A1_HUMAN antibody;SF3a120 antibody;Spliceosome associated protein 114 antibody;Spliceosome-associated protein 114 antibody;Splicing factor 3 subunit 1 antibody;Splicing factor 3a subunit 1 120kDa antibody;Splicing factor 3A subunit 1 antibody

SUBCELLULAR LOCATION

Nucleus, Nucleus speckle.

FUNCTION

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.