SESN2 / Sestrin-2 Recombinant Rabbit Monoclonal Antibody [PSH05-78] (HA722489)

UNIPROT #

P58004

PROTEIN NAME

SESN2 / Sestrin-2

SYNONYMS

DKFZp761M0212 antibody;DKFZp761M02121 antibody;Hi95 antibody;Hypoxia induced gene 95 antibody;MGC11758 antibody;OTTHUMP00000003641 antibody;OTTMUSP00000010184 antibody;RP23 63D8.3 antibody;SES2 antibody;SESN 2 antibody;SESN2 antibody;SESN2_HUMAN antibody;SEST2 antibody;Sestrin 2 antibody;Sestrin-2 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Sestrin-2 also known as Hi95 is a protein that in humans is encoded by the SESN2 gene. This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. The Sestrins constitute a family of evolutionarily-conserved stress-inducible proteins that suppress oxidative stress and regulate adenosine monophosphate-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling. By virtue of these activities, the Sestrins serve as important regulators of metabolic homeostasis. Accordingly, inactivation of Sestrin genes in invertebrates resulted in diverse metabolic pathologies, including oxidative damage, fat accumulation, mitochondrial dysfunction and muscle degeneration that resemble accelerated tissue aging.