Antithrombin III / ATIII / SERPINC1 Mouse Monoclonal Antibody [15F1] (EM1901-11)

UNIPROT #

P01008

PROTEIN NAME

SERPINC1

SYNONYMS

ANT3_HUMAN antibody;Antithrombin antibody;Antithrombin III antibody;Antithrombin-III antibody;AntithrombinIII antibody;AT 3 antibody;AT III antibody;AT3 antibody;AT3D antibody;ATIII antibody;Heparin cofactor I antibody;MGC22579 antibody;Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody;Serine cysteine proteinase inhibitor clade C member 1 antibody;Serine proteinase inhibitor clade C member 1 antibody;Serpin C1 antibody;Serpin family C member 1 antibody;Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody;SERPINC1 antibody;THPH7 antibody

SEQUENCE SIMILARITIES

Belongs to the serpin family.

TISSUE SPECIFICITY

Found in plasma.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by FAM20C in the extracellular medium.

SUBCELLULAR LOCATION

Extracellular space or secreted.

FUNCTION

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.