Serotonin transporter Recombinant Rabbit Monoclonal Antibody [PSH19-18] (HA724052)

UNIPROT #

Q60857

PROTEIN NAME

Serotonin transporter

SYNONYMS

5 HTT antibody;5 HTTLPR antibody;5 hydroxytryptamine (serotonin) transporter antibody;5 hydroxytryptamine transporter antibody;5HT transporter antibody;5HTT antibody;hSERT antibody;HTT antibody;Na+/Cl- dependent serotonin transporter antibody;OCD1 antibody;SC6A4_HUMAN antibody;Serotonin transporter 1 antibody;SERT antibody;SERT1 antibody;Slc6a4 antibody;Sodium dependent serotonin transporter antibody;Sodium-dependent serotonin transporter antibody;Solute carrier family 6 (neurotransmitter transporter) member 4 antibody;solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 antibody;Solute carrier family 6 member 4 antibody

SUBCELLULAR LOCATION

Cell membrane, Endomembrane system, Endosome membrane, Synapse, Cell junction, focal adhesion, Cell projection, neuron projection.

FUNCTION

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. Many antidepressant medications of the SSRI and tricyclic antidepressant classes work by binding to SERT and thus reducing serotonin reuptake. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.