SDHC Recombinant Rabbit Monoclonal Antibody [JE77-46] (HA722584)

UNIPROT #

Q99643

PROTEIN NAME

SDHC

SYNONYMS

CYB560 antibody;C560_HUMAN antibody;CYBL antibody;Cytochrome B large subunit of complex II antibody;Integral membrane protein CII-3 antibody;mitochondrial antibody;PGL3 antibody;QPs-1 antibody;QPs1 antibody;SDH3 antibody;sdhC antibody;succinate dehydrgenase cytochrome b antibody;succinate dehydrogenase 3, integral membrane subunit antibody;Succinate dehydrogenase complex subunit C antibody;Succinate dehydrogenase complex subunit C integral membrane protein 15kDa antibody;Succinate dehydrogenase cytochrome b560 subunit antibody;Succinate dehydrogenase cytochrome b560 subunit mitochondrial antibody;Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor antibody;Succinate-ubiquinone oxidoreductase cytochrome B large subunit antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

Succinate dehydrogenase complex subunit C, also known as succinate dehydrogenase cytochrome b560 subunit, mitochondrial, is a protein that in humans is encoded by the SDHC gene. This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with pheochromocytomas and paragangliomas. Alternatively spliced transcript variants have been described.