Scramblase 1 Rabbit Polyclonal Antibody (HA500063)

UNIPROT #

O15162

PROTEIN NAME

Scramblase 1

SYNONYMS

Ca(2+) dependent phospholipid scramblase 1 antibody;Ca(2+)-dependent phospholipid scramblase 1 antibody;Erythrocyte phospholipid scramblase antibody;MM1 cell-derived transplantability-associated gene 1b, mouse, homolog of antibody;MmTRA1a antibody;MmTRA1b antibody;Nor1 antibody;Phospholipid scramblase 1 antibody;PL scramblase 1 antibody;PLS1_HUMAN antibody;PLSCR 1 antibody;Plscr1 antibody;Scramblase1 antibody;Tra1 antibody;Tra1a antibody;Tra1b antibody;Transplantability-associated protein 1 antibody;Tras1 antibody;Tras2 antibody

SUBCELLULAR LOCATION

Cell membrane, Nucleus, Membrane, Cytoplasm, perinuclear region.

FUNCTION

Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5. Phospholipid scramblase 1 (PLSCR1), a lipid-binding protein that enters the nucleus via the nonclassical NLS (257)GKISKHWTGI(266). The structure of the nuclear localisation sequence of scramblase PLSCR1 complexed to importin was determined using X-ray diffraction with a resolution of 2.20 Ångströms. It is found in most mammals including humans. The import sequence lacks a continuous stretch of positively charged residues, and it is enriched in hydrophobic residues. Thus, Scramblase can transport negatively charged phospholipids from the inside of the cell to the outside of the cell. The importin structure is composed of many alpha helices that integrate the protein into membranes. The role of importin is to move proteins such as scramblase into the nucleus.