Scavenging Receptor SR-BI Recombinant Rabbit Monoclonal Antibody [SR37-06] (ET1602-32)
Catalog# ET1602-32
Rabbit Monoclonal to Scavenging Receptor SR-BI
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WB
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IF-Cell
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IHC-P
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Human
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Mouse
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Rat
Lane 1: HepG2 cell lysate (15 µg/Lane)
Lane 2: Human liver tissue lysate (20 µg/Lane)
Lane 3: Mouse liver tissue lysate (20 µg/Lane)
Lane 4: Rat liver tissue lysate (20 µg/Lane)
Predicted band size: 61 kDa
Observed band size: 75 kDa
Exposure time: 3 minutes 17 seconds;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (ET1602-32) at 1/2,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Scavenging Receptor SR-BI Recombinant Rabbit Monoclonal Antibody [SR37-06] (ET1602-32)
Immunogen
Synthetic peptide within human srb1 aa 81-130 / 552.
Host
Rabbit
Positive Control
HepG2 cell lysate, human liver tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, CRC, PC-12, human liver tissue, human spleen tissue, mouse liver tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
SR37-06
RRID
APPLICATION DILUTION
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WB
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1:2,000
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IF-Cell
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1:50
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 61 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Scavenging Receptor SR-BI
SYNONYMS
CD36 and LIMPII analogous 1 antibody;CD36 antibody;CD36 Antigen like 1 antibody;CD36 antigen-like 1 antibody;CD36L1 antibody;CLA 1 antibody;CLA-1 antibody;CLA1 antibody;Collagen type I receptor antibody;HDLQTL6 antibody;MGC138242 antibody;SCARB1 antibody;Scavebger Receptor Class B Member 1 antibody;Scavenger receptor class B member 1 antibody;Scavenger Receptor Class B Type 1 antibody;SCRB1_HUMAN antibody;SR BI antibody;SR-BI antibody;SRB1 antibody;SRBI antibody;Thrombospondin receptor like 1 antibody;thrombospondin receptor-like 1 antibody
SEQUENCE SIMILARITIES
Belongs to the CD36 family.
TISSUE SPECIFICITY
Widely expressed.
POST-TRANSLATIONAL MODIFICATION
N-glycosylated.; The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
SUBCELLULAR LOCATION
Cell membrane, caveola.
FUNCTION
The macrophage class A scavenger receptors (SR-A) type I and II mediate the uptake of modified low density lipoprotein (LDL), while the scavenger receptor class B type 1 (SR-B1) mediates the selective uptake of cholesterol and cholesterol esters (CE) from HDLs into cells. SREC, Ox-LDL-R1, SR-A and SR-B1 may all be involved in the early development of atherosclerosis. SR-B1, an integral membrane protein, acts as a receptor for various ligands, including apoptotic cells, cholesterol ester, phospholipids, lipoproteins and phosphatidyl-serine. SR-B1, which may be involved in phagocytosis of apoptotic cells, enables the movement of cholesterol between the cell surface and extracellular donors and acceptors. Although it is widely expressed, SR-B1 localizes primarily to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
CITATIONS
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Li Bo,et al
The anti-hyperlipidemia effect of Atractylodes macrocephala Rhizome (AM)-increased HDL via reverse cholesterol transfer (RCT)
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WB
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Rat
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Citation
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Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis
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WB
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Human
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Citation
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