SATB2 Recombinant Antibody [JM52-44] - Rat IgG1 (Chimeric) (HA601569)

UNIPROT #

Q9UPW6

PROTEIN NAME

SATB2

SYNONYMS

DNA binding protein SATB2 antibody;DNA-binding protein SATB2 antibody;FLJ21474 antibody;FLJ32076 antibody;GLSS antibody;KIAA1034 antibody;MGC119474 antibody;MGC119477 antibody;SATB family member 2 antibody;SATB homeobox 2 antibody;SATB2 antibody;SATB2_HUMAN antibody;Special AT rich sequence binding protein 2 antibody;Special AT-rich sequence-binding protein 2 antibody

SUBCELLULAR LOCATION

Nucleus matrix.

FUNCTION

SATB2 (Special AT-rich sequence-binding protein 2) is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.