UNIPROT #

P0DTC9

PROTEIN NAME

SARS-CoV-2 Nucleocapsid Protein

SYNONYMS

SARS-CoV-2 Nucleocapsid Protein antibody; SARS-CoV-2 NP antibody; nucleocapsid protein antibody; novel coronavirus N Protein antibody; novel coronavirus Nucleocapsid Protein antibody; 2019-nCoV Nucleoprotein antibody; 2019-nCoV N antibody; 2019nCoV N antibody; 2019-nCoV N Protein antibody; 2019 peak N Protein antibody; 2019-nCoV nucleocapsid protein antibody

SUBCELLULAR LOCATION

Cytoplasm of SARS-CoV-2.

FUNCTION

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.