SARS-CoV-2 Nucleocapsid Protein Mouse Monoclonal Antibody [A4D12] (EM1902-21)

UNIPROT #

P0DTC9

PROTEIN NAME

SARS-CoV-2 Nucleocapsid Protein

SYNONYMS

SARS-CoV-2 Nucleocapsid Protein antibody;SARS-CoV-2 NP antibody;nucleocapsid protein antibody;novel coronavirus N Protein antibody;novel coronavirus Nucleocapsid Protein antibody;2019-nCoV Nucleoprotein antibody;2019-nCoV N antibody;2019nCoV N antibody;2019-nCoV N Protein antibody;2019 peak N Protein antibody;2019-nCoV nucleocapsid protein antibody

SEQUENCE SIMILARITIES

Belongs to the betacoronavirus nucleocapsid protein family.

POST-TRANSLATIONAL MODIFICATION

ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.; Phosphorylated on serine and threonine residues.

SUBCELLULAR LOCATION

Virion, Host endoplasmic reticulum-Golgi intermediate compartment, Host Golgi apparatus.

FUNCTION

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.