SAMM50 Recombinant Rabbit Monoclonal Antibody [JE61-49] (HA720059)

UNIPROT #

Q9Y512

PROTEIN NAME

SAMM50

SYNONYMS

CGI 51 antibody;CGI-51 antibody;FLJ35825 antibody;FLJ42905 antibody;FLJ99036 antibody;OMP85 antibody;SAM50 antibody;SAM50_HUMAN antibody;Samm50 antibody;sorting and assembly machinery 50kDa antibody;sorting and assembly machinery component 50 homolog (S. cerevisiae) antibody;Sorting and assembly machinery component 50 homolog antibody;sorting and assembly machinery component 50, S. cerevisiae, homolog of antibody;TOB55 antibody;Transformation-related gene 3 protein antibody;TRG-3 antibody;YNL026W antibody

SUBCELLULAR LOCATION

Mitochondrion outer membrane, Mitochondrion, Cytoplasm.

FUNCTION

Sam50 (sorting assembly machinery component 50 homolog, S. cerevisiae), also known as SAMM50, OMP85, TOB55, TRG-3, CGI-51 or YNL026W, is a β-barrel multi-pass membrane protein that belongs to the SAM50/omp85 family of proteins. Localizing to the mitochondrion, Sam50 is believed to function in the assembly pathway of mitochondrial outer membrane β-barrel proteins. More specifically, Sam50 functions as the major component of the SAM (sorting and assembly machinery) complex, also known as the TOB (topogenesis of mitochondrial outer membrane β-barrel proteins) complex, and is required for cell viability. Exposed to the intermembrane space (IMS), the N-terminal POTRA (polypeptide transport-associated) domain of Sam50 (a domain that is conserved from bacteria to man) functions like a receptor for β-barrel proteins. The association of the Sam35 subunit of the SAM complex is essential for Sam50 binding to outer membrane substrate proteins.