Sall4 Rabbit Polyclonal Antibody (HA500482)

UNIPROT #

Q9UJQ4

PROTEIN NAME

Sall4

SYNONYMS

AA407717 antibody;AL022809 antibody;AW536104 antibody;C330011P20Rik antibody;C78083 antibody;C78563 antibody;dJ1112F19.1 antibody;DRRS antibody;HSAL4 antibody;Sal like 4 (Drosophila) antibody;Sal like 4 antibody;Sal like Protein 4 antibody;Sal-like protein 4 antibody;Sall4 antibody;SALL4_HUMAN antibody;Spalt like transcription factor 4 antibody;Tex20 antibody;Zinc finger protein 797 antibody;Zinc finger protein SALL4 antibody;ZNF797 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Sal-like protein 4 (SALL4) is a transcription factor encoded by a member of the Spalt-like (SALL) gene family, SALL4. The SALL genes were identified based on their sequence homology to Spalt, which is a homeotic gene originally cloned in Drosophila melanogaster that is important for terminal trunk structure formation in embryogenesis and imaginal disc development in the larval stages.[7][8] There are four human SALL proteins (SALL1, 2, 3, and 4) with structural homology and playing diverse roles in embryonic development, kidney function, and cancer.[9] The SALL4 gene encodes at least three isoforms, termed A, B, and C, through alternative splicing, with the A and B forms being the most studied. SALL4 can alter gene expression changes through its interaction with many co-factors and epigenetic complexes. It is also known as a key embryonic stem cell (ESC) factor. The various SALL4-null mouse models mimic human mutations in the SALL4 gene, which were shown to cause developmental problems in patients with Okihiro/Duane-Radial-ray syndrome. SALL4 expression is low to undetectable in most adult tissues with the exception of germ cells and human blood progenitor cells. In breast cancer, Signal transducer and activator of transcription 3 (STAT3) has been reported to directly activate SALL4 expression.