SAE2 / UBA2 Recombinant Rabbit Monoclonal Antibody [JM66-53] (ET1705-73)

UNIPROT #

Q9UBT2

PROTEIN NAME

SAE2/ UBA2

SYNONYMS

Anthracycline associated resistance ARX antibody;Anthracycline-associated resistance ARX antibody;ARX antibody;FLJ13058 antibody;HRIHFB2115 antibody;SAE 2 antibody;SAE2 antibody;SAE2_HUMAN antibody;SUMO 1 activating enzyme subunit 2 antibody;SUMO activating enzyme subunit 2 antibody;SUMO-activating enzyme subunit 2 antibody;UBA2 antibody;UBA2 ubiquitin activating enzyme E1 homolog antibody;Ubiquitin like 1 activating enzyme E1B antibody;Ubiquitin like modifier activating enzyme 2 antibody;Ubiquitin-like 1-activating enzyme E1B antibody;UBLE1B antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin-activating E1 family.

POST-TRANSLATIONAL MODIFICATION

Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

The small ubiquitin-related modifier protein SUMO-1 belongs to the ubiquitin-like protein family, which are synthesized as precursor proteins that undergo processing before conjugation to target proteins. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processes, including nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO-1 utilizes homologues of the E1 and E2 enzymes for conjugation to proteins, which include IkBα, MDM2, p53, PML, and RanGap1. AOS1 is homologous to the N-terminal half of E1 and UBA2 is homologous to the C-terminal half of E1. These proteins form a heterodimer that activates SUMO-1.