SAA4 Recombinant Rabbit Monoclonal Antibody [JE47-81] (ET7109-69)

UNIPROT #

P35542

PROTEIN NAME

SAA4

SYNONYMS

Amyloid A, serum, 4 antibody;C SAA antibody;C-SAA antibody;Constitutively expressed serum amyloid A protein antibody;CSAA antibody;SAA 4 antibody;Saa4 antibody;SAA4 protein antibody;SAA4_HUMAN antibody;Serum amyloid A 4 protein antibody;Serum amyloid A-4 protein antibody;Serum amyloid A4 constitutive antibody

SEQUENCE SIMILARITIES

Belongs to the SAA family.

TISSUE SPECIFICITY

Expressed by the liver; secreted in plasma.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Serum amyloid A (SAA) proteins are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs). These proteins are produced predominantly by the liver. Acute-phase serum amyloid A proteins (A-SAAs) are secreted during the acute phase of inflammation. These proteins have several roles, including the transport of cholesterol to the liver for secretion into the bile, the recruitment of immune cells to inflammatory sites, and the induction of enzymes that degrade extracellular matrix. A-SAAs are implicated in several chronic inflammatory diseases, such as amyloidosis, atherosclerosis, and rheumatoid arthritis. Serum amyloid A (SAA) is also an acute phase marker that responds rapidly. Similar to CRP, levels of acute-phase SAA increase within hours after inflammatory stimulus, and the magnitude of increase may be greater than that of CRP. Relatively trivial inflammatory stimuli can lead to SAA responses. It has been suggested that SAA levels correlate better with disease activity in early inflammatory joint disease than do ESR and CRP. Although largely produced by hepatocytes, more recent studies show that SAA is produced by adipocytes as well, and its serum concentration is associated with body mass index.