S100P Recombinant Rabbit Monoclonal Antibody [JF95-08] (ET1702-82)

UNIPROT #

P25815

PROTEIN NAME

S100P

SYNONYMS

MIG9 antibody;Migration inducing gene 9 antibody;Protein S100-E antibody;Protein S100-P antibody;Protein S100P antibody;S100 calcium binding protein P antibody;S100 calcium-binding protein P antibody;S100 P antibody;S100E antibody;S100P antibody;S100P_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the S-100 family.

TISSUE SPECIFICITY

Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Cell projection.

FUNCTION

S-100 proteins are small dimeric members of the EF-Hand superfamily that participate in moderating intracellular calcium signals by binding to and regulating specific proteins in a calcium-dependent manner. S-100P is a survival factor that is associated with different types of tumors and can bind and regulate effector proteins. R1881, a synthetic androgen, regulates S-100P expression. S-100P interacts with a receptor for advanced glycation end products (RAGE) and activates it, thereby increasing the rates of cell growth, division, migration and invasion. This suggests that S-100P acts in an auto-crine manner through RAGE to trigger cell proliferation and survival. S-100P may also positively affect anchorage-independent growth to improve tumor formation. S-100P monomers strongly interact with one another, but not with other S-100 polypeptides, suggesting that homodimer formation is necessary for S-100P to function. The S-100P dimers are then stabilized by hydrophobic contacts.