RYR3 Rabbit Polyclonal Antibody (ER1803-92)

UNIPROT #

Q15413

PROTEIN NAME

RYR3

SYNONYMS

Brain ryanodine receptor-calcium release channel;Brain-type ryanodine receptor;Type 3 ryanodine receptor;Ryanodine receptor 3;Brain ryanodine receptor calcium release channel antibody;Brain type ryanodine receptor antibody;Cardiac muscle ryanodine receptor calcium release channel antibody;Cardiac muscle type ryanodine receptor antibody;CCO antibody;Central core disease of muscle antibody;HBRR antibody;MHS antibody;Ryanodine receptor 3 antibody;Ryanodine receptor type1 antibody;RYDR antibody;RYR 3 antibody;RYR antibody;RYR3 antibody;Sarcoplasmic reticulum calcium release channel antibody;Skeletal muscle calcium release channel antibody;Skeletal muscle ryanodine receptor antibody;Skeletal muscle type ryanodine receptor antibody;Skeletal muscle-type ryanodine receptor antibody;SKRR antibody;VTSIP antibody

SEQUENCE SIMILARITIES

Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily.

TISSUE SPECIFICITY

Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus.

SUBCELLULAR LOCATION

Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum.

FUNCTION

The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.