RTN3 Recombinant Rabbit Monoclonal Antibody [PSH0-40] (HA721342)

UNIPROT #

O95197

PROTEIN NAME

RTN3

SYNONYMS

ASYIP antibody;Neuroendocrine specific protein like 2 antibody;Neuroendocrine-specific protein-like 2 antibody;Neuroendocrine-specific protein-like II antibody;NSP like protein II antibody;NSP-like protein 2 antibody;NSP-like protein II antibody;NSPL2 antibody;NSPLII antibody;Reticulon 3 antibody;Reticulon-3 antibody;Reticulon3 antibody;Rtn3 antibody;RTN3_HUMAN antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Golgi apparatus membrane.

FUNCTION

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIG-I/DDX58, subsequently impairing DDX58 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.