RRP42 Recombinant Rabbit Monoclonal Antibody [JE55-72] (ET7111-13)

UNIPROT #

Q15024

PROTEIN NAME

RRP42

SYNONYMS

EAP1 antibody;EXOS7_HUMAN antibody;Exosc7 antibody;Exosome complex component RRP42 antibody;Exosome complex exonuclease RRP42 antibody;Exosome component 7 antibody;FLJ26543 antibody;hRrp42p antibody;KIAA0116 antibody;p8 antibody;Ribosomal RNA processing protein 42 antibody;Ribosomal RNA-processing protein 42 antibody;RRP42 antibody;Rrp42p antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.