RRM1 Recombinant Rabbit Monoclonal Antibody [JB09-43] (ET7107-72)

UNIPROT #

P23921

PROTEIN NAME

RRM1

SYNONYMS

R1 antibody;Ribonucleoside diphosphate reductase large subunit antibody;Ribonucleoside diphosphate reductase M1 chain antibody;Ribonucleoside diphosphate reductase subunit M1 antibody;Ribonucleoside reductase, large subunit antibody;Ribonucleoside-diphosphate reductase large subunit antibody;Ribonucleoside-diphosphate reductase subunit M1 antibody;Ribonucleotide reductase large chain antibody;Ribonucleotide reductase large subunit antibody;Ribonucleotide reductase M1 antibody;Ribonucleotide reductase M1 polypeptide antibody;Ribonucleotide reductase R1 subunit antibody;Ribonucleotide reductase, M1 subunit antibody;RIR 1 antibody;RIR1 antibody;RIR1_HUMAN antibody;RR 1 antibody;RR1 antibody;RRM 1 antibody;RRM1 antibody

SEQUENCE SIMILARITIES

Belongs to the ribonucleoside diphosphate reductase large chain family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.