RPS27A Rabbit Polyclonal Antibody (HA500371)

UNIPROT #

P62979

PROTEIN NAME

RPS27A

SYNONYMS

40S ribosomal protein S27a antibody;CEP 80 antibody;CEP80 antibody;HUBCEP 80 antibody;HUBCEP80 antibody;Ribosomal protein S27a antibody;RPS 27A antibody;UBA 80 antibody;UBA80 antibody;UBCEP 1 antibody;UBCEP 80 antibody;UBCEP1 antibody;UBCEP80 antibody;Ubiquitin 40S ribosomal protein S27a antibody;Ubiquitin and ribosomal protein S27a antibody;Ubiquitin carboxyl extension protein 80 antibody;Ubiquitin CEP80 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.