RON Recombinant Rabbit Monoclonal Antibody [SD2006] (ET1612-80)

UNIPROT #

Q04912

PROTEIN NAME

RON

SYNONYMS

c met related tyrosine kinase antibody;CD136 antibody;CD136 antigen antibody;CDw136 antibody;Macrophage stimulating 1 receptor (c met related tyrosine kinase) antibody;Macrophage stimulating 1 receptor antibody;Macrophage stimulating protein receptor alpha chain antibody;MACROPHAGE STIMULATING PROTEIN RECEPTOR antibody;Macrophage stimulating protein receptor beta chain antibody;Macrophage-Stimulating 1 Receptor (MST1R) antibody;Macrophage-stimulating protein receptor beta chain antibody;MSP receptor antibody;Mst1r antibody;MST1R variant RON30 antibody;MST1R variant RON62 antibody;NPCA3 antibody;p185 RON antibody;p185-Ron antibody;Protein-tyrosine kinase 8 antibody;PTK 8 antibody;ptk8 antibody;PTK8 protein tyrosine kinase 8 antibody;Recepteur d’origine nantais (RON) antibody;RON antibody;RON protein tyrosine kinase antibody;RON variant E2E3 antibody;RON_HUMAN antibody;Soluble RON variant 1 antibody;Soluble RON variant 2 antibody;Soluble RON variant 3 antibody;Soluble RON variant 4 antibody;Stem cell derived tyrosine kinase antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family.

TISSUE SPECIFICITY

Expressed in colon, skin, lung and bone marrow.

POST-TRANSLATIONAL MODIFICATION

Proteolytic processing yields the two subunits.; Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site.; Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Receptor protein tyrosine kinases (PTKs) have been classified into different subclasses on the basis of sequence similarity and distinct structural characteristics. The c-Met encoded receptor represents the initial member of one class of receptors characterized by a heterodimeric structure and a cysteine-rich extracellular domain. Ron, also designated macrophage-stimulating protein receptor (MSP receptor), p185-Ron, CD136 antigen or PTK8 represents a second member of this receptor class. The intracellular PTK domains of Ron and Met are highly similar (63% sequence identity) while the extracellular domains are less related (25% sequence identity) and both are rich in cysteine residues. Mature Ron receptor is comprised of a disulfide-linked heterodimer formed from an alpha chain (Ron α) and a beta chain (Ron β). Proteolytic processing results in the separation of the N-terminal Ron α and C-terminal Ron β subunits.