UNIPROT #

O75116

PROTEIN NAME

ROCK2

SYNONYMS

coiled-coil-containing protein kinase 2 antibody; KIAA0619 antibody; p164 ROCK 2 antibody; p164 ROCK-2 antibody; Rho associated coiled coil containing protein kinase 2 antibody; Rho associated protein kinase 2 antibody; Rho associated, coiled coil containing protein kinase II antibody; Rho kinase 2 antibody; Rho-associated antibody; Rho-associated protein kinase 2 antibody; ROCK 2 antibody; Rock II antibody; Rock2 antibody; ROCK2_HUMAN antibody; Rock2m antibody; ROK alpha antibody; ROKalpha antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

TISSUE SPECIFICITY

Expressed in the brain (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics. Dephosphorylation by PTPN11 stimulates its RHOA binding activity.; Cleaved by granzyme B during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.

SUBCELLULAR LOCATION

Plasma membrane. Cytoskeleton. Nucleus.

FUNCTION

Rho, the Ras-related small GTPase, is responsible for the regulation of Actin-based cytoskeletal structures, including stress fibers, focal adhesions and the contractile ring apparatus. Rho proteins function as molecular switches that are able to turn cytokinesis on and off. Although little is known about signaling downstream of Rho, a host of putative Rho effector proteins have been de-scribed, including rhophilin, Rhotekin, citron and the serine/threonine kinase, protein kinase N. Two additional Rho-activated serine/threonine kinases have been described, designated Rock-1 and Rock-2 (also referred to as Roka) for Rho-associated coil-containing protein kinase. Rock-1 and Rock-2 share a structural similarity with myotonic dystrophy kinase.