ROCK1 Rabbit Polyclonal Antibody (ER40122)

UNIPROT #

Q13464

PROTEIN NAME

ROCK1

SYNONYMS

coiled-coil-containing protein kinase 1 antibody;coiled-coil-containing protein kinase I antibody;MGC131603 antibody;MGC43611 antibody;p160 Rhoassociated coiled coil-forming protein kinase antibody;p160 ROCK-1 antibody;p160 ROCK1 antibody;p160ROCK antibody;PRO0435 antibody;Renal carcinoma antigen NY REN 35 antibody;Renal carcinoma antigen NY-REN-35 antibody;Rho associated coiled coil containing protein kinase 1 antibody;Rho associated protein kinase 1 antibody;Rho kinase antibody;Rho-alpha kinase antibody;Rho-associated antibody;Rho-associated protein kinase 1 antibody;ROCK I antibody;ROCK-I antibody;ROCK1 antibody;ROCK1_HUMAN antibody;Rok antibody;rokalpha antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

TISSUE SPECIFICITY

Detected in blood platelets.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylated on serine and threonine residues.; Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.

SUBCELLULAR LOCATION

Cytoplasm, cell membrane, Nucleus, Cell projection, Cytoskeleton, Golgi apparatus, Membrane.

FUNCTION

ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. ROCK1 has a ubiquitous tissue distribution, but subcellularly it is thought to colocalize with the centrosomes. This is consistent with its function as a key modulator of cell motility, tumor cell invasion, and actin cytoskeleton organization. ROCK1 has a diverse range of functions in the body. It is a key regulator of actin-myosin contraction, stability, and cell polarity. These contribute to many progresses such as regulation of morphology, gene transcription, proliferation, differentiation, apoptosis and oncogenic transformation. Other functions involve smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility. These functions are activated by phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A.