RNF40 Recombinant Rabbit Monoclonal Antibody [JE46-30] (ET7109-46)

UNIPROT #

O75150

PROTEIN NAME

RNF40

SYNONYMS

95 kDa retinoblastoma associated protein antibody;95 kDa retinoblastoma protein binding protein antibody;95 kDa retinoblastoma-associated protein antibody;BRE 1B antibody;BRE1 B antibody;BRE1 E3 ubiquitin ligase homolog B antibody;BRE1-B antibody;BRE1B antibody;BRE1B_HUMAN antibody;DKFZp686K191 antibody;E3 ubiquitin protein ligase BRE1B antibody;E3 ubiquitin-protein ligase BRE1B antibody;KIAA0661 antibody;MGC13051 antibody;Rb associated protein antibody;RBP 95 antibody;RBP95 antibody;RING finger protein 40 antibody;Ring finger protein 40 E3 ubiquitin protein ligase antibody;RNF 40 antibody;Rnf40 antibody;STARING antibody

SEQUENCE SIMILARITIES

Belongs to the BRE1 family.

TISSUE SPECIFICITY

Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene. The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.