RIPK2 Recombinant Rabbit Monoclonal Antibody [JE51-90] (HA721300)

UNIPROT #

O43353

PROTEIN NAME

RIPK2

SYNONYMS

CARD 3 antibody;CARD carrying kinase antibody;CARD containing ICE associated kinase antibody;CARD containing IL 1 beta ICE kinase antibody;CARD containing IL1 beta ICE kinase antibody;CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase antibody;CARD containing interleukin 1 beta converting enzyme associated kinase antibody;CARD-containing IL-1 beta ICE-kinase antibody;CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody;CARD3 antibody;CARDIAK antibody;CCK antibody;CLARP kinase antibody;GIG 30 antibody;GIG30 antibody;Growth inhibiting gene 30 antibody;Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase antibody;Receptor interacting protein 2 antibody;Receptor interacting serine threonine kinase 2 antibody;Receptor interacting serine/threonine protein kinase 2 antibody;Receptor-interacting protein 2 antibody;Receptor-interacting serine/threonine-protein kinase 2 antibody;RICK antibody;RIP 2 antibody;RIP like interacting CLARP kinase antibody;RIP-2 antibody;RIP-like-interacting CLARP kinase antibody;RIPK 2 antibody;Ripk2 antibody;RIPK2_HUMAN antibody;TNFRSF antibody;Tyrosine-protein kinase RIPK2 antibody;UNQ277/PRO314/PRO34092 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Also plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. Plays a role in the inactivation of RHOA in response to NGFR signaling. Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.