RING2 Recombinant Rabbit Monoclonal Antibody [JB38-41] (ET7107-07)

UNIPROT #

Q99496

PROTEIN NAME

RING2

SYNONYMS

BAP 1 antibody;BAP1 antibody;DING antibody;DinG protein antibody;E3 ubiquitin protein ligase RING 2 antibody;E3 ubiquitin protein ligase RING2 antibody;E3 ubiquitin-protein ligase RING2 antibody;HIP2 interacting protein 3 antibody;HIP2-interacting protein 3 antibody;HIPI 3 antibody;HIPI3 antibody;Huntingtin interacting protein 2 interacting protein 3 antibody;Huntingtin-interacting protein 2-interacting protein 3 antibody;OTTHUMP00000060668 antibody;Polycomb M33 interacting protein Ring 1B antibody;Polycomb M33 interacting protein Ring1B antibody;Protein DinG antibody;RING 1B antibody;RING 2 antibody;RING finger protein 1B antibody;RING finger protein 2 antibody;RING finger protein BAP 1 antibody;RING finger protein BAP-1 antibody;RING finger protein BAP1 antibody;RING1b antibody;RING2_HUMAN antibody;RNF 2 antibody;Rnf2 antibody

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated in the presence of UBE2D3 (in vitro).; Monoubiquitinated, by auto-ubiquitination.

SUBCELLULAR LOCATION

Chromosome. Nucleus.

FUNCTION

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable).