RhoGDI Rabbit Polyclonal Antibody (HA500067)

UNIPROT #

P52565

PROTEIN NAME

RhoGDI

SYNONYMS

ARHGDIA antibody;fa96g11 antibody;GDIA 1 antibody;GDIA1 antibody;GDIR1_HUMAN antibody;MGC117248 antibody;NPHS8 antibody;Rho GDI 1 antibody;Rho GDI alpha antibody;Rho GDI antibody;Rho GDP dissociation inhibitor (GDI) alpha antibody;Rho GDP dissociation inhibitor 1 antibody;Rho GDP dissociation inhibitor alpha antibody;Rho GDP-dissociation inhibitor 1 antibody;Rho-GDI alpha antibody;RhoGDI 1 antibody;RhoGDI alpha antibody;RHOGDI antibody;RhoGDI1 antibody;wu:fa96g11 antibody;zgc:55554 antibody;zgc:77681 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants.