Lane 1: SiHa cell lysate
Lane 2: HepG2 cell lysate
Recombinant Rabbit monoclonal primary
RhoGAP Recombinant Rabbit Monoclonal Antibody [JE53-53] (ET7110-65)
Synthetic peptide within c-terminal human rhogap.
SiHa cell lysate, HepG2 cell lysate, SiHa.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
ARHGAP 5 antibody; ARHGAP5 antibody; p190 B antibody; p190 RhoGAP antibody; Rho GTPase activating protein 5 antibody; RhoGAP 5 antibody; RhoGAP antibody; RhoGAP5 antibody
Detected in skin fibroblasts (at protein level).
Cell membrane, cytoplasm.
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP. Impaired autophagic degradation of lncRNA ARHGAP5-AS1 in chemoresistant cancer cells promoted chemoresistance. It can activate the transcription of ARHGAP5 in the nucleus and stimulate m6A modification of ARHGAP5 mRNA to stabilize ARHGAP5 mRNA in the cytoplasm by recruiting METTL3. Therefore, targeting ARHGAP5-AS1/ARHGAP5 axis might be a promising strategy to overcome chemoresistance in gastric cancer.