Rem2 Rabbit Polyclonal Antibody (R1510-14)

UNIPROT #

Q8IYK8

PROTEIN NAME

Rem2

SYNONYMS

cb111 antibody;chunp6884 antibody;etID309896.20 antibody;R2 antibody;reductase M2 polypeptide variant 1 antibody;reductase M2 polypeptide variant 2 antibody;reductase M2 polypeptide variant 3a antibody;reductase M2 polypeptide variant 3b antibody;reductase M2 polypeptide variant 3c antibody;reductase M2 polypeptide variant 3d antibody;Ribonucleoside-diphosphate reductase subunit M2 antibody;Ribonucleotide reductase M2 antibody;Ribonucleotide reductase M2 polypeptide antibody;Ribonucleotide reductase M2 subunit antibody;ribonucleotide reductase protein r2 class I antibody;Ribonucleotide reductase regulatory subunit M2 antibody;Ribonucleotide reductase small chain antibody;Ribonucleotide reductase small subunit antibody;Ribonucleotide reductase, R2 subunit antibody;RIR2_HUMAN antibody;RR2 antibody;RR2M antibody;RRM2 antibody

SEQUENCE SIMILARITIES

Belongs to the small GTPase superfamily. RGK family.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

REM2 (RAS (RAD and GEM)-like GTP binding 2) is a 340 amino acid cell membrane protein that functions as a GTPase and belongs to the RGK family as well as the small GTPase superfamily. A suppressor of the p53 pathway, REM2 also mediates the fibroblastic growth factor 2 (FGF-2) signaling pathway and is involved in maintaining the proliferation of human embryonic stem cells. Expressed in kidney and brain, REM2 is encoded by a gene that maps to human chromosome 14q11.2. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.