RDC1 Recombinant Rabbit Monoclonal Antibody [SN65-09] (ET1611-3)

UNIPROT #

P25106

PROTEIN NAME

RDC1

SYNONYMS

ACKR3 antibody;atypical chemokine receptor 3 antibody;C X C chemokine receptor type 7 antibody;C-X-C chemokine receptor type 7 antibody;Chemokine (C-X-C motif) receptor 7 antibody;Chemokine C X C motif receptor 7 antibody;Chemokine orphan receptor 1 antibody;CMKOR1 antibody;CXC R7 antibody;CXC-R7 antibody;CXCR 7 antibody;CXCR-7 antibody;CXCR7 antibody;CXCR7_HUMAN antibody;G protein coupled receptor 159 antibody;G protein coupled receptor antibody;G protein coupled receptor RDC1 homolog antibody;G-protein coupled receptor 159 antibody;G-protein coupled receptor RDC1 homolog antibody;GPR159 antibody;GPRN1 antibody;RDC 1 antibody;RDC-1 antibody;RDC1 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.

TISSUE SPECIFICITY

Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level).

POST-TRANSLATIONAL MODIFICATION

The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.; Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.

SUBCELLULAR LOCATION

Cell membrane, Early endosome, Recycling endosome, perinuclear region.

FUNCTION

Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene. This protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP) and was considered to be an orphan receptor. It is now classified as a chemokine receptor able to bind the chemokines CXCL12/SDF-1 and CXCL11. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Whereas some reports claim that the receptor induces signaling following ligand binding, recent findings in zebrafish suggest that CXCR7 functions primarily by sequestering the chemokine CXCL12.