RBPJK Recombinant Rabbit Monoclonal Antibody [JB49-34] (ET7107-22)

UNIPROT #

Q06330

PROTEIN NAME

RBPJK

SYNONYMS

AI843960 antibody;AOS3 antibody;CBF 1 antibody;CBF-1 antibody;CBF1 antibody;csl antibody;IGKJRB antibody;IGKJRB1 antibody;J kappa recombination signal binding protein antibody;J kappa-recombination signal-binding protein antibody;KBF2 antibody;NY REN 30 antigen antibody;RBP J antibody;RBP J kappa antibody;RBP JK antibody;RBP-J antibody;RBP-J kappa antibody;RBP-JK antibody;Rbpj antibody;RBPJK antibody;RBPSUH antibody;recombination signal binding protein for immunoglobulin kappa J region antibody;Recombining binding protein suppressor of hairless antibody;Renal carcinoma antigen NY-REN-30 antibody;SUH antibody;SUH_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the Su(H) family.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Recombination signal binding protein Jκ (RBP-Jκ), also designated KBF2 or CBF1, is the mammalian homolog of the Drosophila suppressor of hairless (Su(H)), a protein involved in the development of the peripheral nervous system. RBP-Jκ is ubiquitously expressed in mammalian tissues and is involved in the regulation of gene expression. RBP-Jκ has been shown to directly interact with the intercellular domain of the cell surface receptor Notch 1. Proteolytically cleaved Notch 1 translocates to the nucleus, where it binds DNA-bound RBP-Jκ and activates transcription of target genes. These genes include NFκB p52 and the Epstein-Barr virus (EBV) protein EBNA-2, both of which contain RBP-Jκ-binding sequences within their promoter regions.