RBBP5 Rabbit Polyclonal Antibody (HA500395)

UNIPROT #

Q15291

PROTEIN NAME

RBBP5

SYNONYMS

RBBP 5 antibody;RBBP-5 antibody;RBBP5 antibody;RBBP5_HUMAN antibody;RBQ 3 antibody;RBQ3 antibody;Retinoblastoma binding protein 5 antibody;Retinoblastoma binding protein RBQ3 antibody;Retinoblastoma binding protein5 antibody;Retinoblastoma-binding protein 5 antibody;Retinoblastoma-binding protein RBQ-3 antibody;SWD1 antibody;SWD1, Set1c WD40 repeat protein, homolog antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.