Recombinant Rabbit monoclonal primary
RANTES Recombinant Rabbit Monoclonal Antibody [JM03-45] (ET1705-70)
Mouse thymus tissue lysate, Hela, HUVEC, human tonsil tissue, human breast cancer tissue, human lung caner tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Beta chemokine RANTES antibody; Beta chemokine RANTES precursor antibody; C C motif chemokine 5 antibody; CCL 5 antibody; CCL5 antibody; CCL5_HUMAN antibody; Chemokine (C C motif) ligand 5 antibody; Chemokine CC Motif Ligand 5 antibody; D17S136E antibody; EoCP antibody; Eosinophil chemotactic cytokine antibody; MGC17164 antibody; RANTES(4-68) antibody; Regulated upon activation normally T expressed and presumably secreted antibody; SCYA 5 antibody; SCYA5 antibody; SIS delta antibody; SIS-delta antibody; SISd antibody; Small inducible cytokine A5 (RANTES) antibody; Small inducible cytokine A5 antibody; Small inducible cytokine subfamily A (Cys Cys) member 5 antibody; Small-inducible cytokine A5 antibody; T cell specific protein p288 antibody; T cell specific RANTES protein antibody; T cell-specific protein P228 antibody; T-cell-specific protein RANTES antibody; TCP 228 antibody; TCP228 antibody
Belongs to the intercrine beta (chemokine CC) family.
Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.
N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.; The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.