RALA Recombinant Rabbit Monoclonal Antibody [JE54-12] (HA721215)

UNIPROT #

P11233

PROTEIN NAME

RALA

SYNONYMS

MGC48949 antibody;Ral a antibody;Ral A protein antibody;RAL antibody;RALA antibody;RALA_HUMAN antibody;Ras family small GTP binding protein RALA antibody;RAS like protein A antibody;Ras related protein RalA antibody;Ras-related protein Ral-A antibody;v ral simian leukemia viral oncogene homolog A (ras related) antibody;v ral simian leukemia viral oncogene homolog A antibody

SUBCELLULAR LOCATION

Cell membrane, Mitochondrion.

FUNCTION

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1.