RACK1 Recombinant Rabbit Monoclonal Antibody [JG40-26] (ET7109-04)

UNIPROT #

P63244

PROTEIN NAME

RACK1

SYNONYMS

Cell proliferation-inducing gene 21 protein antibody;GBLP_HUMAN antibody;Gnb2-rs1 antibody;Gnb2l1 antibody;Guanine nucleotide binding protein (G protein) beta polypeptide 2 like 1 antibody;Guanine nucleotide binding protein beta polypeptide 2 like 1 antibody;Guanine nucleotide binding protein beta subunit 2 like 1 antibody;Guanine nucleotide binding protein beta subunit like protein 12.3 antibody;Guanine nucleotide binding protein subunit beta 2 like 1 antibody;Guanine nucleotide binding protein subunit beta like protein 12.3 antibody;Guanine nucleotide-binding protein subunit beta-2-like 1 antibody;Guanine nucleotide-binding protein subunit beta-like protein 12.3 antibody;H12.3 antibody;HLC-7 antibody;Human lung cancer oncogene 7 protein antibody;lung cancer oncogene 7 antibody;OTTHUMP00000223704 antibody;OTTHUMP00000223870 antibody;OTTHUMP00000223891 antibody;OTTHUMP00000223893 antibody;OTTHUMP00000223900 antibody;OTTHUMP00000223902 antibody;OTTHUMP00000223930 antibody;OTTHUMP00000223931 antibody;PIG21 antibody;Proliferation inducing gene 21 antibody;Protein homologous to chicken B complex protein guanine nucleotide binding antibody;RACK1 antibody;Receptor for activated C kinase 1 antibody;Receptor for activated C kinase antibody;Receptor of activated protein kinase C 1 antibody

SEQUENCE SIMILARITIES

Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

TISSUE SPECIFICITY

In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC.; (Microbial infection) Phosphorylated by vaccinia virus B1 kinase on serine and threonine residues; this phosphorylation remodels the ribosome properties, favoring the viral mRNA translation.

SUBCELLULAR LOCATION

Cytoplasm. Cell membrane. Nucleus.

FUNCTION

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. Receptor for activated C kinases, termed RACKs, are intracellular receptors for activated PKC that may be involved in the activation-induced translocation of PKC. RACK1 (receptor for activated C kinase 1) is a 317 amino acid G protein b subunit-like protein that functions as a RACK and inhibits the activity of Src tyrosine kinases. In response to PKC activation, the intracellular localization of RACK1 and PKC bII changes, and RACK1 and PKC bII co-localize to the same sites. RACK1 is therefore thought to be a shuttling protein for PKC bII. A deficit in RACK1 may be associated with impaired PKC activation in the aging brain. The RACK1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, rice and P.falciparum, and maps to human chromosome 5q35.3.