RAB8A Recombinant Rabbit Monoclonal Antibody [JE64-79] (HA721127)

UNIPROT #

P61006

PROTEIN NAME

RAB8A

SYNONYMS

AA409338 antibody;MEL antibody;Mel transforming oncogene (derived from cell line NK14) RAB8 homolog antibody;Mel transforming oncogene (derived from cell line NK14) antibody;Mel transforming oncogene (RAB8 homolog) antibody;Mel transforming oncogene antibody;MGC124948 antibody;Oncogene c mel antibody;Oncogene c-mel antibody;RAB8 antibody;RAB8A antibody;RAB8A member RAS oncogene family antibody;RAB8A_HUMAN antibody;Ras associated protein RAB8 antibody;Ras related protein Rab 8A antibody;Ras-related protein Rab-8A antibody

SUBCELLULAR LOCATION

Cell membrane, golgi apparatus, recycling endosome membrane, cytoplasm, centriole, cilium basal body, cilium axoneme, cilium, phagosome, phagosome membrane, midbody.

FUNCTION

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.