RAB11FIP3 Rabbit Polyclonal Antibody (ER1902-80)

UNIPROT #

O75154

PROTEIN NAME

Rab11-FIP3

SYNONYMS

EF hands containing Rab interacting protein antibody;Eferin antibody;Rab11 family interacting protein 3 antibody;RAB11FIP3 antibody;RFIP3 antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase.

SUBCELLULAR LOCATION

Recycling endosome membrane, centrosome, Cleavage furrow, Midbody.

FUNCTION

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track).