PUMA Rabbit Polyclonal Antibody (ER31215)

UNIPROT #

Q9BXH1

PROTEIN NAME

PUMA

SYNONYMS

BBC 3 antibody;Bbc3 antibody;BBC3_HUMAN antibody;BCL 2 binding component 3 antibody;Bcl-2-binding component 3 antibody;BCL2 binding component 3 antibody;JFY 1 antibody;JFY-1 antibody;JFY1 antibody;p53 up regulated modulator of apoptosis antibody;p53 up-regulated modulator of apoptosis antibody;p53 Upregulated Modulator of Apoptosis antibody;PUMA alpha antibody;PUMA/JFY1 antibody

SEQUENCE SIMILARITIES

Belongs to the Bcl-2 family.

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria. Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death. Several studies have shown that PUMA function is affected or absent in cancer cells. Additionally, many human tumors contain p53 mutations, which results in no induction of PUMA, even after DNA damage induced through irradiation or chemotherapy drugs.Other cancers, which exhibit overexpression of antiapotptic Bcl-2 family proteins, counteract and overpower PUMA-induced apoptosis.