PTPRF/LAR Rabbit Polyclonal Antibody (R1510-12)

UNIPROT #

P10586

PROTEIN NAME

PTPRF/LAR

SYNONYMS

FLJ43335 antibody;FLJ45062 antibody;FLJ45567 antibody;LAR antibody;LAR protein antibody;LARFN5C antibody;LARS antibody;LCA homolog antibody;Leukocyte antigen related (LAR) PTP receptor antibody;Leukocyte antigen related antibody;Leukocyte antigen related PTP receptor antibody;Leukocyte antigen related tyrosine phosphatase antibody;Leukocyte common antigen related antibody;Protein Tyrosine Phosphatase Receptor Type F antibody;Protein tyrosine phosphatase receptor type F polypeptide antibody;Ptprf antibody;PTPRF protein antibody;PTPRF_HUMAN antibody;Receptor linked protein tyrosine phosphatase LAR antibody;Receptor type tyrosine protein phosphatase F antibody;Receptor type tyrosine protein phosphatase F precursor antibody;Receptor-type tyrosine-protein phosphatase F antibody

SEQUENCE SIMILARITIES

Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.