PTBP1 Rabbit Polyclonal Antibody (R1403-2)

UNIPROT #

P26599

PROTEIN NAME

PTBP1

SYNONYMS

57 kDa RNA binding protein PPTB 1 antibody;57 kDa RNA-binding protein PPTB-1 antibody;Heterogeneous nuclear ribonucleoprotein I antibody;Heterogeneous Nuclear Ribonucleoprotein Polypeptide I antibody;hnRNP I antibody;HNRNP-I antibody;HNRNPI antibody;HNRPI antibody;MGC10830 antibody;MGC8461 antibody;Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) antibody;Polypyrimidine Tract Binding Protein 1 antibody;Polypyrimidine tract binding protein antibody;Polypyrimidine tract-binding protein 1 antibody;pPTB antibody;PTB 1 antibody;PTB 2 antibody;PTB 3 antibody;PTB 4 antibody;PTB antibody;PTB T antibody;PTB1 antibody;PTB2 antibody;PTB3 antibody;PTB4 antibody;PTBP 1 antibody;PTBP1 antibody;PTBP1_HUMAN antibody;PTBT antibody;RNA Binding Protein antibody

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. It plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. PTBP1 activates exon skipping of its own pre-mRNA during muscle cell differentiation. It binds to the polypyrimidine tract of introns and may promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. PTBP1 may promote the binding of U2 snRNP to pre-mRNA. It cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.