PTBP1 Mouse Monoclonal Antibody [5C1] (M1701-7)

UNIPROT #

P26599

PROTEIN NAME

PTBP1

SYNONYMS

57 kDa RNA binding protein PPTB 1 antibody;57 kDa RNA-binding protein PPTB-1 antibody;Heterogeneous nuclear ribonucleoprotein I antibody;Heterogeneous Nuclear Ribonucleoprotein Polypeptide I antibody;hnRNP I antibody;HNRNP-I antibody;HNRNPI antibody;HNRPI antibody;MGC10830 antibody;MGC8461 antibody;Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) antibody;Polypyrimidine Tract Binding Protein 1 antibody;Polypyrimidine tract binding protein antibody;Polypyrimidine tract-binding protein 1 antibody;pPTB antibody;PTB 1 antibody;PTB 2 antibody;PTB 3 antibody;PTB 4 antibody;PTB antibody;PTB T antibody;PTB1 antibody;PTB2 antibody;PTB3 antibody;PTB4 antibody;PTBP 1 antibody;PTBP1 antibody;PTBP1_HUMAN antibody;PTBT antibody;RNA Binding Protein antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome. The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. hnRNP I, also designated polypyrimidine tract-binding protein (PTB), and its homolog hnRNP L bind to the 3' end of introns to modulate alternative splicing mechanisms of pre-mRNAs in normal cells and the translation of several viruses, including hepatitis C virus (HCV). The human hnRNP I gene maps to chromosome 19p13.3 and encodes a protein that is localized in the nucleoplasm. hnRNP L, like hnRNP I, is also localized in the nucleoplasm.