PSMD2 Rabbit Polyclonal Antibody (HA500353)

UNIPROT #

Q13200

PROTEIN NAME

PSMD2

SYNONYMS

26S proteasome non-ATPase regulatory subunit 2 antibody;26S proteasome regulatory subunit RPN1 antibody;26S proteasome regulatory subunit S2 antibody;26S proteasome subunit p97 antibody;55.11 protein antibody;MGC14274 antibody;P97 antibody;Proteasome (prosome macropain) 26S subunit non ATPase 2 antibody;Proteasome 26S subunit, non-ATPase, 2 antibody;Proteasome 26S, subunit 2 antibody;Protein 55.11 antibody;Psmd2 antibody;PSMD2_HUMAN antibody;Rpn1 antibody;S2 antibody;TNFR associated protein 2 antibody;TRAP2 antibody;Tumor necrosis factor receptor associated protein 2 antibody;Tumor necrosis factor type 1 receptor-associated protein 2 antibody

SUBCELLULAR LOCATION

Cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus, proteasome storage granule.

FUNCTION

26S proteasome non-ATPase regulatory subunit 2, also as known as 26S Proteasome Regulatory Subunit Rpn1 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD2 gene. As the degradation machinery that is responsible for ~70% of intracellular proteolysis, proteasome complex (26S proteasome) plays a critical roles in maintaining the homeostasis of cellular proteome. Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; in parallel, some key regulatory proteins fulfill their biological functions via selective degradation; furthermore, proteins are digested into peptides for MHC class I antigen presentation.